We know a lot about the most famous medicine against a bad erection. But, each patient is interisuet all the properties of the drug, which he uses. Efficiency and the desired result is only one side of the coin. Pharmacokinetic properties include the absorption rate of the remedy, its distribution, metabolic processes, and excretion. For a long time did not feel like a full-fledged man who can give minutes, and maybe hours of enjoying his beloved woman? To restore men’s strength, you do not need to use folk remedies that can only exacerbate the problem! And even more so, you can not leave everything to “self”.
Viagra Soft is a drug that has proven itself to treat sexual disorders in a strong half of humanity, and also to increase potency.
Compared with conventional drugs to increase potency, Viagra Soft is much more convenient and easier to use, and it starts to act much faster, because it does not need to be swallowed, but simply should be dissolved under the tongue.
Absorption
Viagra Soft is normally absorbed in a short time. The concentration of the drug in the blood after ingestion reaches its maximum effect in 20-120 minutes. The average value is noted in 60 minutes. Full bioavailability of Viagra Soft is approximately 41%. The availability interval has the following percentages: from 25% to 63%. After using Viagra Soft pills for Canadians from 25 mg to 100 mg, the pharmacokinetics are linear. After using the drug in combination with high-calorie food, the rate of absorption of the active substance is reduced to a negligible extent.
Viagra is quickly absorbed. Concentration of the drug in the plasma after taking it inside fasting reaches a peak for 30-120 minutes (an average of 60 minutes). Absolute bioavailability when ingested on average is 41% (25-63%). When taking Viagra in combination with fatty food, the rate of absorption decreases.
Distribution
The volume fraction distribution of sildenafil, the basic component of the drug, is approximately 105 liters in a static arrangement, which means its dispersal in the muscles of the genital organ. The main substance of sildenafil, circulating M-desmethyl metabolite, binds to blood proteins by 96%.
The total concentration of the Viagra Soft for Canadians does not depend on its connection with proteins. In healthy subjects who were tested, the following concentration of the remedy was determined in the seed in 1.5 hours after the use of the drug: 0.0002%. With a single use of 100 mg, 188 ng was found.
Metabolism
The sildenafil substance is concentrated solely under the action of CYP3A4, as the main pathway and CYP2C9, as an additional, in the microsomal isoenzyme of the liver. Based on the selectivity of the effect on phosphodiesterase, the metabolite is commensurable with the substance sildenafil .Its intensification by type 5 PDE compiles approximately 50% than the intensity of the remedy itself.
The concentration of the metabolite in the blood is approximately 40% than the concentration of sildenafil in it .M- desmethyl metabolite substance undergoes further metabolism. The complete half-life of the substance is about 4 hours.
Excretion
The excretion period of sildenafil from the human blood is 41 liters per hour. The maximum half-life is up to 5 hours. Sometime later after ingestion or through intravenous administration, the substance is excreted to a greater extent, forming metabolites (almost 80% of the dose used) with a caloric mass and to the least extent (less than 20%) in the urine.
The effectiveness of Viagra, which was assessed by the ability of the remedy to ensure the onset and preservation of an erection sufficient for intercourse, was demonstrated in all 21 studies and persisted with long-term treatment (one year). When using the remedy in fixed doses, the proportion of patients noted improvement in erectile function was 62 ° (25 mg), 74% (50 mg) and 82 ° (100 mg), and with placebo – 25%. In addition to improving erectile function, the IIEF analysis showed that Viagra’s treatment also improves orgasm, satisfaction from sexual intercourse and general satisfaction. In all studies, the proportion of patients with diabetes mellitus who noted improvement in the treatment of Viagra was 59%, patients who underwent radical prostatectomy – 43%, patients with spinal cord injury – 83% (compared to 16%, 15% and 12% of patients receiving placebo, respectively).